Package: bfbin2arm 0.1.4

Riko Kelter

bfbin2arm: Bayes Factor Design for Two-Arm Binomial Trials

Design and analysis of one- and two-stage binomial clinical phase II trials using Bayes factors. Implements Bayes factors for point-null and directional hypotheses, predictive densities under different hypotheses, and power and sample size calibration. Both one-arm trials with only a single treatment arm and two-arm trials with treatment and control arm are implemented for the one- and two-stage designs.

Authors:Riko Kelter [aut, cre]

bfbin2arm_0.1.4.tar.gz
bfbin2arm_0.1.4.zip(r-4.7)bfbin2arm_0.1.4.zip(r-4.6)bfbin2arm_0.1.4.zip(r-4.5)
bfbin2arm_0.1.4.tgz(r-4.6-any)bfbin2arm_0.1.4.tgz(r-4.5-any)
bfbin2arm_0.1.4.tar.gz(r-4.7-any)bfbin2arm_0.1.4.tar.gz(r-4.6-any)
bfbin2arm_0.1.4.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
bfbin2arm/json (API)

# Install 'bfbin2arm' in R:
install.packages('bfbin2arm', repos = c('https://rikokelter.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/rikokelter/bfbin2arm/issues

Pkgdown/docs site:https://rikokelter.github.io

On CRAN:

Conda:

4.04 score 11 scripts 452 downloads 27 exports 27 dependencies

Last updated from:7b1a70514e. Checks:9 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-devel-x86_64OK162
source / vignettesOK325
linux-release-x86_64OK164
macos-release-arm64OK130
macos-oldrel-arm64OK170
windows-develOK107
windows-releaseOK98
windows-oldrelOK167
wasm-releaseOK101

Exports:BFminus0BFminus1BFplus0BFplus1BFplusMinusdesign_singlearm_bfdesign_singlearm_onestage_bfdesign_singlearm_onestage_ropedesign_twoarm_onestage_bfdesign_twoarm_twostage_bfntwoarmbinbf01optimal_twostage_2arm_bfoptimal_twostage_singlearm_bfplot_twostage_2arm_bfpostProbHminuspostProbHpluspowerbinbf01_fixedpowerbinbf01seqpowertwoarmbinbf01predictiveDensityH0predictiveDensityH1predictiveDensityHminus_truncpredictiveDensityHplus_truncpriorProbHminuspriorProbHplustwoarmbinbf_plus0_directtwoarmbinbf01

Dependencies:clicpp11dplyrfarvergenericsggplot2gluegtableisobandlabelinglifecyclemagrittrpatchworkpillarpkgconfigR6RColorBrewerrlangS7scalestibbletidyselectutf8vctrsVGAMviridisLitewithr

Bayesian calibration of two-arm one-stage Bayes factor designs with binary endpoints

| Riko Kelter | Institute of Medical Statistics and Computational Biology | Faculty of Medicine | University of Cologne | Cologne, Germany

Rendered frombfbin2arm-twoarm_onestage_Bayesian.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Calibration of Bayesian one-stage designs for single-arm phase II trials with binary endpoints

Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany

Rendered frombfbin2arm-singlearm-onestage.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Clinical trial designs in bfbin2arm

Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany

Rendered frombfbin2arm-overview.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Frequentist and hybrid calibration of one-stage ROPE-based designs for single-arm phase II trials

| Riko Kelter | Institute of Medical Statistics and Computational Biology | Faculty of Medicine | University of Cologne | Cologne, Germany

Rendered frombfbin2arm-rope-singlearm-onestage-calibration.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Optimal Bayesian calibration for single-arm two-stage Bayes factor designs

| Riko Kelter | Institute of Medical Statistics and Computational Biology | Faculty of Medicine | University of Cologne | Cologne, Germany

Rendered frombfbin2arm-singlearm-twostage_bayesian.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Optimal Bayesian calibration of two-arm two-stage Bayes factor designs with binary endpoints

| Riko Kelter | Institute of Medical Statistics and Computational Biology | Faculty of Medicine | University of Cologne | Cologne, Germany

Rendered frombfbin2arm-twoarm-twostage_Bayesian.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Optimal frequentist calibration for single-arm two-stage Bayes factor designs with binary endpoints

Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany

Rendered frombfbin2arm-singlearm_twostage_frequentist.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Optimal full calibration for single-arm two-stage Bayes factor designs with binary endpoints

Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany

Rendered frombfbin2arm-singlearm_twostage_full.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Optimal hybrid calibration for single-arm two-stage Bayes factor designs with binary endpoints

Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany

Rendered frombfbin2arm-singlearm_twostage_hybrid.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

ROPE-based trial design for single-arm one-stage phase II trials with binary endpoints

| Riko Kelter | Institute of Medical Statistics and Computational Biology | Faculty of Medicine | University of Cologne | Cologne, Germany

Rendered frombfbin2arm-rope-singlearm-onestage-design.Rmdusingknitr::rmarkdownon Jun 24 2026.

Last update: 2026-06-23
Started: 2026-06-23

Readme and manuals

Help Manual

Help pageTopics
Check sustained feasibility over future n.sustained_singlearm_feasibility
Convert a one-stage single-arm BF design to a data frameas.data.frame.singlearm_onestage_bf_design
Bayes factor BF-0: H- vs H0BFminus0
Bayes factor BF-1: H- vs H1BFminus1
Bayes factor BF+0: H+ vs H0BFplus0
Bayes factor BF+1: H+ vs H1BFplus1
Bayes factor BF+-: H+ vs H-BFplusMinus
Design or evaluate a single-arm two-stage Bayes factor trialdesign_singlearm_bf
Design or evaluate a one-stage single-arm Bayes factor trialdesign_singlearm_onestage_bf
Calibrate a one-stage single-arm ROPE design for a binomial endpointdesign_singlearm_onestage_rope
Design or evaluate a one-stage two-arm Bayes factor trialdesign_twoarm_onestage_bf
Design an optimal two-stage two-arm Bayes factor trialdesign_twoarm_twostage_bf
Sample size calibration for two-arm binomial Bayes factor designsntwoarmbinbf01
Internal calibration routine for one-stage single-arm BF designsoptimal_onestage_singlearm_bf
Internal calibration routine for one-stage two-arm BF designsoptimal_onestage_twoarm_bf
Optimal two-stage two-arm Bayes-factor design for binary endpointsoptimal_twostage_2arm_bf
Optimal two-stage single-arm Bayes factor designoptimal_twostage_singlearm_bf
Plot an optimal two-stage two-arm Bayes factor designplot_twostage_2arm_bf
Plot a single-arm Bayes factor designplot.singlearm_bf_design
Plot a one-stage single-arm BF designplot.singlearm_onestage_bf_design
Posterior probability P(p2 <= p1 | data)postProbHminus
Posterior probability P(p2 > p1 | data) under independent Beta priorspostProbHplus
Bayesian and frequentist operating characteristics for a fixed-sample single-arm BF designpowerbinbf01_fixed
Bayesian and frequentist operating characteristics for a single-arm two-stage BF designpowerbinbf01seq
Bayesian power, type-I error, and PCE(H0) for two-arm binomial Bayes factorspowertwoarmbinbf01
Predictive density under H0: p1 = p2 = ppredictiveDensityH0
Predictive density under H1: p1 != p2predictiveDensityH1
Predictive density under H-: p2 <= p1 (truncated prior)predictiveDensityHminus_trunc
Predictive density under H+: p2 > p1 (truncated prior)predictiveDensityHplus_trunc
Print method for one-stage single-arm BF designsprint.singlearm_onestage_bf_design
Print method for summary.singlearm_bf_designprint.summary.singlearm_bf_design
Print method for summaries of one-stage single-arm BF designsprint.summary.singlearm_onestage_bf_design
Prior probability P(p2 <= p1) under independent Beta priorspriorProbHminus
Prior probability P(p2 > p1) under independent Beta priorspriorProbHplus
Summary for single-arm BF designssummary.singlearm_bf_design
Summarize a one-stage single-arm BF designsummary.singlearm_onestage_bf_design
Bayes factor BF+0 for the directional alternative vs point-nulltwoarmbinbf_plus0_direct
Two-arm binomial Bayes factor BF01twoarmbinbf01